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Article

Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.

1 Aug 2000

Abstract excerpt

5-Fluorouracil (5-FU), 5-fluoro-2'-deoxyuridine (FdUrd) and 5-trifluorothymidine (F3(d)Thd) are antimetabolites which are metabolized to their corresponding active forms which inhibit DNA synthesis via inhibition of thymidylate synthase (TS). To investigate ways of overcoming 5-FU-resistance, we established acquired-resistant colorectal cancer cell lines against these three drugs by continuous and step-wise...

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PMID: 10891536
DOI: 10.3892/ijo.17.2.277

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