Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

Anticancer research - 1 May 2013

Frey Christian R, Andrei Graciela, Votruba Ivan, Cannizzaro Carina, Han Bin, Fung Wanchi, Hung Magdeleine, Liu Xiaohong, Geleziunas Romas, Fiten Pierre, Opdenakker Ghislain, Snoeck Robert, Cihlar Tomas

Abstract excerpt

BACKGROUND/AIM: GS 9219 is a double prodrug of antiproliferative nucleotide analog 9-(2-Phosphonylmethoxyethyl)guanine (PMEG), with potent in vivo efficacy against various hematological malignancies. This study investigates the role of adenosine deaminase-like (ADAL) protein in the intracellular activation of GS-9219. MATERIALS AND METHODS: A cell line resistant to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Alanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Drug Resistance, Neoplasm

Share to Prodrugs

Share to Purines

Share to Tumor Cells, Cultured

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 23645737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.PMID 23645737Read ↗

Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell LineSemantic proximity Read ↗

Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.Semantic proximity Read ↗

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and CongenersSemantic proximity Read ↗

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.Semantic proximity Read ↗

2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.Semantic proximity Read ↗

Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.Semantic proximity Read ↗

Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.Semantic proximity Read ↗

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.Semantic proximity Read ↗

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.Semantic proximity Read ↗

Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes.Semantic proximity Read ↗

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.