Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Aug 1999

Gimm O, Greco A, Hoang-Vu C, Dralle H, Pierotti M A, Eng C

Abstract excerpt

Tyrosine kinase NTRK1 is expressed in neural and nonneuronal tissues. Like RET, NTRK1 is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC). Because of similarities in involvement of the two tyrosine kinases RET (rearranged during transfection) and NTRK1 in the pathogenesis of PTC, the obvious parallels between RET and NTRK1 and between PTC and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Medullary
Share to Exons
Share to Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Receptor Protein-Tyrosine Kinases

Share to Receptor, trkA

Share to Receptors, Nerve Growth Factor

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 10443680
DOI: 10.1210/jcem.84.8.5901

Genes

NTRK1
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma.PMID 10443680Read ↗

RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic mutations in RET exons 12 and 15 in sporadic medullary thyroid carcinomas: different spectrum of mutations in sporadic type from hereditary type.Semantic proximity Read ↗

Somatic mutations in the RET protooncogene in Japanese and Chinese sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Polymorphisms in the RET proto-oncogene and the phenotypic presentation of familial medullary thyroid carcinoma.Semantic proximity Read ↗

Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

A single missense mutation in codon 918 of the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Three novel mutations in the RET proto-oncogene.Semantic proximity Read ↗

Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type.Semantic proximity Read ↗

Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation.Semantic proximity Read ↗

Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Somatic trinucleotide change encompassing codons 882 and 883 of the RET proto-oncogene in a patient with sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.