Article
On the resolution and feasibility of genome scanning approaches.
Advances in genetics - 1 Jan 2001
Terwilliger J D
Abstract excerpt
Before contemplating a genome scan to identify the map position of disease-predisposing genes, an investigator should have prior evidence of the genes' existence. It is therefore logically consistent to evaluate a genome scan experiment as an estimation problem, rather than as a hypothesis-testing problem, since absent prior evidence of the existence of disease genes, it is probably unwise to conduct the...
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