Article
Computer simulation of linkage and heterogeneity in tuberous sclerosis: a critical evaluation of the collaborative family data.
Journal of medical genetics - 1 Dec 1992
Janssen L A, Sandkuijl L A, Sampson J R, Halley D J
Abstract excerpt
The existence of locus heterogeneity for a genetic disease may complicate linkage studies considerably, especially when very few large families with the disease are available. In this situation a modest collection of families is unlikely to be sufficient for successful localisation of one or more disease genes. Recently, eight research groups working on tuberous sclerosis (TSC) brought together linkage data...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Computer Simulation
- DNA
- Family Health
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Humans
- Lod Score
- Models, Genetic