Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.

American journal of human genetics - 1 Sept 1999

Chen C C, Lu R B, Chen Y C, Wang M F, Chang Y C, Li T K, Yin S J

Abstract excerpt

The genes that encode the major enzymes of alcohol metabolism, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), exhibit functional polymorphism. The variant alleles ADH2*2 and ADH3*1, which encode high-activity ADH isoforms, and the ALDH2*2 allele, which encodes the low-activity form of ALDH2, protect against alcoholism in East Asians. To investigate possible interactions among these protective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase

Share to Ethanol

Share to Isoenzymes

Share to Logistic Models

Share to Multifactorial Inheritance

Share to Taiwan

Source

Open in PubMed Open full text

Identifiers

PMID: 10441588
DOI: 10.1086/302540
PMCID: PMC1377988

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.PMID 10441588Read ↗

Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism.Semantic proximity Read ↗

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.Semantic proximity Read ↗

Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2.Semantic proximity Read ↗

Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.Semantic proximity Read ↗

Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?Semantic proximity Read ↗

Polymorphisms of ethanol metabolizing enzyme genes and alcoholism.Semantic proximity Read ↗

The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese.Semantic proximity Read ↗

Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines.Semantic proximity Read ↗

Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease.Semantic proximity Read ↗

Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes.Semantic proximity Read ↗

Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.