Article
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
American journal of human genetics - 1 Apr 1991
Thomasson H R, Edenberg H J, Crabb D W, Mai X L, Jerome R E, Li T K, Wang S P, Lin Y T, Lu R B, Yin S J
Abstract excerpt
The liver enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. An allele encoding an inactive form of the mitochondrial ALDH2 is known to reduce the likelihood of alcoholism in Japanese. We hypothesized that the polymorphisms of both ALDH and ADH modify the predisposition to development of alcoholism....
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- China
- Gene Frequency
- Genotype
- Humans
- Male
- Polymerase Chain Reaction
- Taiwan