Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease.

doi:10.1093/oxfordjournals.alcalc.a008303

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Article

Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Whitfield J B

Abstract excerpt

The purpose of this paper is to assemble and evaluate existing data on the effect of genetic variation in ADH2 and ADH3 on the risk of alcohol dependence, and on the risk of alcoholic liver disease. Calculations of odds ratios and their confidence limits, and tests for heterogeneity of the results from the available studies, have been performed. It is clear that possession of the ADH2-2 allele decreases the risk...

Topics

Alcohol Dehydrogenase
Alcoholism
Alleles
Genetic Variation
Genotype
Humans
Liver Diseases, Alcoholic
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 9373704
DOI: 10.1093/oxfordjournals.alcalc.a008303

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