Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission.

The Journal of infectious diseases - 1 Sept 1999

Lockett S F, Alonso A, Wyld R, Martin M P, Robertson J R, Gore S M, Leen C L, Brettle R P, Yirrell D L, Carrington M, Brown A J

Abstract excerpt

To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexual human immunodeficiency virus (HIV) transmission, 144 persons heterosexually exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped. A significantly higher frequency of 64I heterozygotes at CCR-2 was observed in HIV-positive than in EU women (P=.02, relative risk=1.6). The allele frequency of 64I...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Heterosexuality

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Seropositivity

Share to Homozygote

Share to Receptors, CCR2

Share to Receptors, CCR5

Share to Receptors, Chemokine

Source

Identifiers

PMID: 10438347
DOI: 10.1086/314918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission.PMID 10438347Read ↗

Combined Effect of CCR5-Δ32 Heterozygosity and the CCR5 Promoter Polymorphism −2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 TransmissionSemantic proximity Read ↗

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population.Semantic proximity Read ↗

Protective effect of CCR5-Δ32 against HIV infection by the heterosexual mode of transmission in a Polish population.Semantic proximity Read ↗

Role of CCR5, CCR2 and SDF-1 gene polymorphisms in a population of HIV-1 infected individuals.Semantic proximity Read ↗

[Effects of CCR5-delta32, CCR2-64I and SDF-1-3'A polymorphic alleles on human immunodeficiency virus 1 (HIV-1) infection in the Polish population].Semantic proximity Read ↗

Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.Semantic proximity Read ↗

CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status.Semantic proximity Read ↗

Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study.Semantic proximity Read ↗

Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individualsSemantic proximity Read ↗

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.Semantic proximity Read ↗

Genetic variations in CC chemokine receptors and hypertension.Semantic proximity Read ↗

Effects of CCR2 and CCRS polymorphisms on HIV-1 infection in Thai females.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.