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Article

Fas Ligand-induced Proinflammatory Transcriptional Responses in Reconstructed Human Epidermis

1 Nov 2007

Abstract excerpt

Fas ligand (FasL) exerts potent proapoptotic and proinflammatory actions on epidermal keratinocytes and has been implicated in the pathogenesis of eczema, toxic epidermal necrolysis, and drug-induced skin eruptions. We used reconstructed human epidermis to investigate the mechanisms of FasL-induced inflammatory responses and their relationships with FasL-triggered caspase activity. Caspase activity was a potent...

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PMID: 17977827
DOI: 10.1074/jbc.m705852200

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