Interleukin-4 deficiency does not exacerbate disease in NOD mice.

doi:10.2337/diab.47.8.1207

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Article

Interleukin-4 deficiency does not exacerbate disease in NOD mice.

Diabetes - 1 Aug 1998

Wang B, Gonzalez A, Höglund P, Katz J D, Benoist C, Mathis D

Abstract excerpt

To investigate the role of interleukin (IL)-4 in the regulation of autoimmune diabetes, we crossed the IL-4 knock-out mutation onto the NOD genetic background. This experiment was accelerated by typing for microsatellites linked to known diabetes susceptibility (Idd) loci, and included a control...

Topics

Alleles
Animals
CD4-Positive T-Lymphocytes
Diabetes Mellitus, Type 1
Hybridization, Genetic
Incidence
Inflammation
Interleukin-4
Interleukin-5
Islets of Langerhans
Mice
Mice, Inbred NOD
Mice, Knockout
Microsatellite Repeats

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