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Article

Interleukin-4 deficiency does not exacerbate disease in NOD mice.

Diabetes - 1 Aug 1998

Wang B, Gonzalez A, Höglund P, Katz J D, Benoist C, Mathis D

Abstract excerpt

To investigate the role of interleukin (IL)-4 in the regulation of autoimmune diabetes, we crossed the IL-4 knock-out mutation onto the NOD genetic background. This experiment was accelerated by typing for microsatellites linked to known diabetes susceptibility (Idd) loci, and included a control backcross of the wild-type 129/SvJ-derived IL-4 gene, the original target locus. We also crossed the mutation into the...

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Identifiers

PMID: 9703318
DOI: 10.2337/diab.47.8.1207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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