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Article

NOD mouse model for Sjögren's syndrome: lack of longitudinal stability.

Oral diseases - 1 Nov 2006

Lodde B M, Mineshiba F, Kok M R, Wang J, Zheng C, Schmidt M, Cotrim A P, Kriete M, Tak P P, Baum B J

Abstract excerpt

OBJECTIVES: The non-obese diabetic (NOD) mouse is not only a widely used model for diabetes mellitus type I, but also for the chronic autoimmune disease Sjögren's syndrome (SS), mainly affecting salivary and lacrimal glands. We studied the efficacy of local recombinant serotype 2 adeno-associated viral (rAAV2) vector transfer of immunomodulatory transgenes to alter the SS-like disease in NOD mice. Data collected...

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Identifiers

PMID: 17054769
DOI: 10.1111/j.1601-0825.2006.01241.x

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