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Article

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.

Oncogene - 8 Jul 1999

Bilanges B, Varrault A, Basyuk E, Rodriguez C, Mazumdar A, Pantaloni C, Bockaert J, Theillet C, Spengler D, Journot L

Abstract excerpt

Loss of chromosome 6q21-qter is the second most frequent loss of chromosomal material in sporadic breast neoplasms suggesting the presence of at least one tumor suppressor gene on 6q. We recently isolated a cDNA encoding a new zinc finger protein which we named ZAC according to its functional properties, namely induction of apoptosis and control of cell cycle progression. ZAC is expressed in normal mammary gland...

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Source

Identifiers

PMID: 10435621
DOI: 10.1038/sj.onc.1202933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.PMID 10435621Read ↗

The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.Semantic proximity Read ↗

<i>hZAC</i> encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancerSemantic proximity Read ↗

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.Semantic proximity Read ↗

Zac1 functional interactions mediate AP-1 transcriptional activity.Semantic proximity Read ↗

Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.Semantic proximity Read ↗

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.Semantic proximity Read ↗

A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.Semantic proximity Read ↗

ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma.Semantic proximity Read ↗

Inhibition of Zac1, a New Gene Differentially Expressed in the Anterior Pituitary, Increases Cell Proliferation*Semantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor γ Is a Zac Target Gene Mediating Zac AntiproliferationSemantic proximity Read ↗

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.Semantic proximity Read ↗

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