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Article

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.

The Journal of biological chemistry - 1 Jun 2001

Varrault A, Bilanges B, Mackay D J, Basyuk E, Ahr B, Fernandez C, Robinson D O, Bockaert J, Journot L

Abstract excerpt

ZAC is a recently isolated zinc finger protein that induces apoptosis and cell cycle arrest. The corresponding gene is imprinted maternally through an unknown mechanism and maps to 6q24-q25, within the minimal interval harboring the gene responsible for transient neonatal diabetes mellitus (TNDM)...

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Share to Chromosomes, Human, Pair 6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Source

Identifiers

PMID: 11297535
DOI: 10.1074/jbc.C100095200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11297535-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.PMID 11297535Read ↗

Transient neonatal diabetes, a disorder of imprinting.Semantic proximity Read ↗

A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus.Semantic proximity Read ↗

A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC.Semantic proximity Read ↗

ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetesSemantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus.Semantic proximity Read ↗

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.Semantic proximity Read ↗

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene networkSemantic proximity Read ↗

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.Semantic proximity Read ↗

Transient neonatal diabetes mellitus type 1.Semantic proximity Read ↗

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMSemantic proximity Read ↗

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