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Article

ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.

Nucleic acids research - 1 Jan 2005

Arima Takahiro, Kamikihara Tetsuya, Hayashida Toshirou, Kato Kiyoko, Inoue Toshiaki, Shirayoshi Yasuaki, Oshimura Mitsuo, Soejima Hidenobu, Mukai Tunehiro, Wake Norio

Abstract excerpt

Loss of genomic imprinting is involved in a number of developmental abnormalities and cancers. ZAC is an imprinted gene expressed from the paternal allele of chromosome 6q24 within a region known to harbor a tumor suppressor gene for several types of neoplasia. p57(KIP2) (CDKN1C) is a maternally expressed gene located on chromosome 11p15.5 which encodes a cyclin-dependent kinase inhibitor that may also act as a...

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Identifiers

PMID: 15888726
DOI: 10.1093/nar/gki555
PMCID: PMC1097765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.PMID 15888726Read ↗

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.Semantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus.Semantic proximity Read ↗

A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC.Semantic proximity Read ↗

Imprinting disruption of the <i>CDKN1C</i>/<i>KCNQ1OT1</i> domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancerSemantic proximity Read ↗

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

<i>Zac1</i> (<i>Lot1</i>), a Potential Tumor Suppressor Gene, and the Gene for ɛ-Sarcoglycan Are Maternally Imprinted Genes: Identification by a Subtractive Screen of Novel Uniparental Fibroblast LinesSemantic proximity Read ↗

The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis.Semantic proximity Read ↗

Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.Semantic proximity Read ↗

The ZIC gene family in development and disease.Semantic proximity Read ↗

An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.Semantic proximity Read ↗

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