Article
The IgG2a/IgA produced by the murine T560 B lymphoma that arose during a graft-versus-host reaction is polyreactive and somatically mutated.
Autoimmunity - 1 Jan 1999
Phillips-Quagliata J M, Faria A M, Han J, Spencer D H, Haughton G, Casali P
Abstract excerpt
In mice undergoing a graft-versus-host (GVH) reaction, donor T cells responding to the host's MHC antigens induce polyclonal activation of the host's B cells and secretion of their antibodies and autoantibodies. T560, a CD5- B lymphoma that arose in the gut-associated lymphoid tissue (GALT) of a (B10 x B10.H2aH4(b)pWts) F1 hybrid mouse that had been injected with parental B10.H2aH4b splenocytes, is of particular...
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