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Article

A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999

Rangarajan S, Woodgate R, Goodman M F

Abstract excerpt

DNA synthesis in Escherichia coli is inhibited transiently after UV irradiation. Induced replisome reactivation or "replication restart" occurs shortly thereafter, allowing cells to complete replication of damaged genomes. At the present time, the molecular mechanism underlying replication restart is not understood. DNA polymerase II (pol II), encoded by the dinA (polB) gene, is induced as part of the global SOS...

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Identifiers

PMID: 10430924
DOI: 10.1073/pnas.96.16.9224
PMCID: PMC17761

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