Article
DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.
Human genetics - 1 Jan 1996
Wenzel K, Ernst M, Rohde K, Baumann G, Speer A
Abstract excerpt
To contribute to the analysis of the genetic background of atherosclerosis, especially endothelial dysfunction, we searched for DNA polymorphisms in the genes encoding E-, P-, and L-selectin, and ICAM-I and VCAM-I. We detected 17 mutations by single-strand conformation polymorphisms analysis and...
Topics
- Adult
- Alleles
- Arteriosclerosis
- Base Sequence
- DNA
- DNA Primers
- E-Selectin
- Female
- Gene Frequency
- Genetic Carrier Screening
- Humans
- Intercellular Adhesion Molecule-1
- L-Selectin
- Male
- Middle Aged
- P-Selectin
- Point Mutation
- Polymerase Chain Reaction