Article
DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.
Human genetics - 1 Jan 1996
Wenzel K, Ernst M, Rohde K, Baumann G, Speer A
Abstract excerpt
To contribute to the analysis of the genetic background of atherosclerosis, especially endothelial dysfunction, we searched for DNA polymorphisms in the genes encoding E-, P-, and L-selectin, and ICAM-I and VCAM-I. We detected 17 mutations by single-strand conformation polymorphisms analysis and direct sequencing. Five of them resulted in an amino acid substitution. In E-selectin, exchanges from serine to...
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