Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Matrix metalloproteinase can facilitate the heparanase-induced promotion of phenotype change in vascular smooth muscle cells.

Atherosclerosis - 1 Jul 1999

Fitzgerald M, Hayward I P, Thomas A C, Campbell G R, Campbell J H

Abstract excerpt

Previous studies from this laboratory have shown that degradation of heparan sulphate proteoglycan by both living macrophages and macrophage lysosomal heparanase induces phenotypic change of vascular smooth muscle cells (SMC) from a high volume fraction of myofilaments (V(v)myo) to a low V(v)myo [Campbell et al. Exp Cell Res 1992; 200: 156-167]. The aim of this study was to determine whether matrix...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Arteriosclerosis
Share to Carotid Arteries

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucuronidase

Share to Glycoside Hydrolases

Share to Metalloendopeptidases

Share to Thiophenes

Share to Thymidine

Source

Identifiers

PMID: 10428300
DOI: 10.1016/s0021-9150(99)00019-2

Genes

MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Matrix metalloproteinase can facilitate the heparanase-induced promotion of phenotype change in vascular smooth muscle cells.PMID 10428300Read ↗

Heparan sulfate-degrading enzymes induce modulation of smooth muscle phenotype.Semantic proximity Read ↗

Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo.Semantic proximity Read ↗

Expression of heparan sulphate N-deacetylase/N-sulphotransferase by vascular smooth muscle cells.Semantic proximity Read ↗

Extracellular matrix-induced cyclooxygenase-2 regulates macrophage proteinase expression.Semantic proximity Read ↗

Relationship of glycosaminoglycan and matrix changes to vascular smooth muscle cell phenotype modulation in rabbit arteries after acute injury.Semantic proximity Read ↗

The macrophage as an initiator of atherosclerosis.Semantic proximity Read ↗

The synthetic metalloproteinase inhibitor batimastat suppresses injury-induced phosphorylation of MAP kinase ERK1/ERK2 and phenotypic modification of arterial smooth muscle cells in vitro.Semantic proximity Read ↗

Phenotypic modulation of smooth muscle cells during the formation of neointimal thickenings in the rat carotid artery after balloon injury: an electron-microscopic and stereological study.Semantic proximity Read ↗

Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms.Semantic proximity Read ↗

Isolation of vascular smooth muscle cell cultures with altered responsiveness to the antiproliferative effect of heparin.Semantic proximity Read ↗

Substrate-induced phenotypical change of monocytes/macrophages into myofibroblast-like cells: a new insight into the mechanism of in-stent restenosis.Semantic proximity Read ↗

Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.