Article
Expression of heparan sulphate N-deacetylase/N-sulphotransferase by vascular smooth muscle cells.
The Histochemical journal - 1 Jan 2000
Bingley John A, Hayward Ian P, Girjes Adeeb A, Campbell Gordon R, Humphries Donald E, Stow Jennifer L, Campbell Julie H
Abstract excerpt
Heparan sulphate is an important mediator in determining vascular smooth muscle cell (SMC) phenotype. The sulphation pattern of the heparan sulphate chains is critical to their function. We have examined the initial step in the biosynthesis of the sulphated domains mediated by the enzyme heparan sulphate N-deacetylase/N-sulphotransferase (NDST). Rabbit aortic SMC in primary culture exhibited NDST enzyme activity...
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