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Article

The macrophage as an initiator of atherosclerosis.

Clinical and experimental pharmacology & physiology - 1 Feb 1991

Campbell J H, Campbell G R

Abstract excerpt

1. Heparan sulfate proteoglycan in the basal lamina of smooth muscle cells is important in the maintenance of the 'contractile', high volume fraction of myofilaments (Vvmyo) phenotype. The mechanism by which this occurs may involve the continuous internalization of heparan sulfate by the smooth muscle cells themselves. 2. One macrophage can degrade all the heparan sulfate from three smooth muscle cells by the...

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Source

Identifiers

PMID: 2022080
DOI: 10.1111/j.1440-1681.1991.tb01411.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A Mathematical Model for Smooth Muscle Cell Phenotype Switching In Atherosclerotic Plaque.Semantic proximity Read ↗

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Through the layers: how macrophages drive atherosclerosis across the vessel wallSemantic proximity Read ↗

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