Heparan sulfate-degrading enzymes induce modulation of smooth muscle phenotype.

doi:10.1016/s0014-4827(05)80084-9

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Article

Heparan sulfate-degrading enzymes induce modulation of smooth muscle phenotype.

Experimental cell research - 1 May 1992

Campbell J H, Rennick R E, Kalevitch S G, Campbell G R

Abstract excerpt

Macrophages cocultured with rabbit aortic smooth muscle cells at a ratio of 1:3 degraded all the 35S-labeled heparan sulfate proteoglycan from the smooth muscle surface into free sulfate (Kav of 0.84 on Sepharose 6B). Concomitantly, the same macrophages induced a decrease in the volume fraction o...

Topics

Animals
Cell Differentiation
Cell Membrane
Cells, Cultured
Heparitin Sulfate
Lysosomes
Macrophages
Muscle, Smooth, Vascular
Phenotype
Polysaccharide-Lyases
Proteoglycans
Rabbits
Sulfur Radioisotopes

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