Article
Implication of HLA-DMA alleles in corsican IDDM.
Disease markers - 1 Nov 1998
Cucchi-Mouillot P, Lai S, Carcassi C, Sorba P, Stuart-Simoni M, Amoros J P, Genetet B, Haras D, Contu L
Abstract excerpt
The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune...
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