Article
HLA-DMA alleles are possible new markers of rheumatoid arthritis: study of a Corsican group.
Experimental and clinical immunogenetics - 1 Jan 1999
Cucchi-Mouillot P, Lai S, Carcassi C, Silicani-Amoros P, Floris L, Amoros J P, Genetet B, Haras D, Contu L
Abstract excerpt
The HLA-DMA gene, along with the HLA-DMB gene, encodes the not classical class II molecule. This molecule catalyzes the class-II-associated invariant-chain peptide (CLIP)-antigen peptide exchange in classical class II molecule peptide-binding groove. As such, the DM heterodimer is an antigen presentation regulator and may be linked to immune system deficiencies such as those observed in autoimmune diseases. The...
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