Article
HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus.
Tissue antigens - 1 Sept 1999
Siegmund T, Donner H, Braun J, Usadel K H, Badenhoop K
Abstract excerpt
The HLA-DMA and HLA-DMB genes are located in the HLA-D region between DQ and DP. Four variants of DMA (DMA*0101-0104) and five of the DMB (DMB*0101-0105) have so far been identified. HLA-DM molecules are required in the process of peptide loading to HLA class II antigens, both regulating the dissociation of class II-associated invariant chain peptides (CLIP) and the subsequent binding of exogenous peptides to HLA...
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