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Article

Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants.

Diabetes - 1 Aug 1999

Kelemen K, Crawford M L, Gill R G, Hutton J C, Wegmann D

Abstract excerpt

The ability of nonobese diabetic (NOD) mice to mount a cellular immune response to the secretory granule protein tyrosine phosphatase (PTP), phogrin was evaluated by immunization of 8- to 12-week-old animals with recombinant phogrin in complete Freund's adjuvant. Draining lymph nodes displayed a robust proliferative response to the protein, as did derived T-cell lines and clones. Ten clones obtained by limiting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Source

Identifiers

PMID: 10426369
DOI: 10.2337/diabetes.48.8.1529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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