RER(+) phenotype in prostate intra-epithelial neoplasia associated with human prostate-carcinoma development.

doi:10.1002/(sici)1097-0215(19990827)82:5<635::aid-ijc3>3.0.co;2-w

Article

RER(+) phenotype in prostate intra-epithelial neoplasia associated with human prostate-carcinoma development.

International journal of cancer - 27 Aug 1999

Miet S M, Neyra M, Jaques R, Dubernard P, Revol A A, Marçais C

Abstract excerpt

The mutator (RER(+)) phenotype has been shown to be a mutational mechanism for tumour-suppressor-gene inactivation in colorectal cancer. A group of 60 prostate-carcinoma patients was studied to determine the frequency, intratumour distribution and timing of mutator phenotype in this cancer. Ten microsatellite loci were analyzed in 172 carcinoma foci (CF) and in 57 associated non-cancerous prostate tissues,...

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RER(+) phenotype in prostate intra-epithelial neoplasia associated with human prostate-carcinoma development.

Abstract excerpt

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