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Article

Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis.

Molecular cancer research : MCR - 1 Jan 2006

Henrique Rui, Jerónimo Carmen, Teixeira Manuel R, Hoque Mohammad O, Carvalho André L, Pais Irene, Ribeiro Franclim R, Oliveira Jorge, Lopes Carlos, Sidransky David

Abstract excerpt

High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma, but the frequency and timing of epigenetic changes found in prostate carcinogenesis has not been extensively documented. Thus, the promoters of three genes (APC, GSTP1, and RARbeta2) involved in prostate carcinogenesis were tested by quantitative methylation-specific PCR in tissue DNA from 30 prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16446401
DOI: 10.1158/1541-7786.MCR-05-0113

Genes

APC
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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