A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.

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Article

A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.

Leukemia - 1 Dec 1992

Duprez E, Ruchaud S, Houge G, Martin-Thouvenin V, Valensi F, Kastner P, Berger R, Lanotte M

Abstract excerpt

We report the isolation of a maturation-resistant acute promyelocytic leukemia (APL) cell line. This permanent cell line, derived from the same patient as the maturation inducible NB4 cell line, is the first retinoid-resistant cell line with a t(15;17) chromosomal translocation. Morphological, im...

Topics

Adult
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Drug Resistance
Female
Humans
Karyotyping
Leukemia, Promyelocytic, Acute
Phenotype
Translocation, Genetic
Tretinoin
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1453773

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1453773-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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