Article
Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.
Leukemia - 1 Feb 2000
Cai X, Shen Y L, Zhu Q, Jia P M, Yu Y, Zhou L, Huang Y, Zhang J W, Xiong S M, Chen S J, Wang Z Y, Chen Z, Chen G Q
Abstract excerpt
Recent studies showed that arsenic trioxide (As2O3) could induce apoptosis and partial differentiation of leukemic promyelocytes. Here, we addressed the possible mechanisms underlying these two different effects. 1.0 microM As2O3-induced apoptosis was associated with condensation of the mitochondrial matrix, disruption of mitochondrial transmembrane potentials (DeltaPsim) and activation of caspase-3 in acute...
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