Article
Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice.
Cancer research - 15 Nov 2002
Engle Sandra J, Ormsby Ilona, Pawlowski Sharon, Boivin Gregory P, Croft Joanne, Balish Edward, Doetschman Tom
Abstract excerpt
Patients with ulcerative colitis are at risk for colon cancer and frequently have microsatellite instability,which, in turn, is usually associated with inactivation of transforming growth factor (TGF) beta signaling. TGF-beta1 deficiency in mice can lead to colon cancer that is preceded by precancerous lesions having submucosal inflammation and hyperplastic crypts. Germ-free TGF-beta1-deficient mice are free of...
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