Article
Cardiac potassium channel dysfunction in sudden infant death syndrome.
Journal of molecular and cellular cardiology - 1 Mar 2008
Rhodes Troy E, Abraham Robert L, Welch Richard C, Vanoye Carlos G, Crotti Lia, Arnestad Marianne, Insolia Roberto, Pedrazzini Matteo, Ferrandi Chiara, Vege Ashild, Rognum Torleiv, Roden Dan M, Schwartz Peter J, George Alfred L
Abstract excerpt
Life-threatening arrhythmias have been suspected as one cause of the sudden infant death syndrome (SIDS), and this hypothesis is supported by the observation that mutations in arrhythmia susceptibility genes occur in 5-10% of cases. However, the functional consequences of cardiac potassium channel gene mutations associated with SIDS and how these alleles might mechanistically predispose to sudden death are...
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