Article
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.
Microbiology (Reading, England) - 1 Jun 1999
Mathee Kalai, Ciofu Oana, Sternberg Claus, Lindum Peter W, Campbell Joan I A, Jensen Per, Johnsen Anders H, Givskov Michael, Ohman Dennis E, Søren Molin, Høiby Niels, Kharazmi Arsalan
Abstract excerpt
The leading cause of mortality in patients with cystic fibrosis (CF) is respiratory failure due in large part to chronic lung infection with Pseudomonas aeruginosa strains that undergo mucoid conversion, display a biofilm mode of growth in vivo and resist the infiltration of polymorphonuclear leukocytes (PMNs), which release free oxygen radicals such as H2O2. The mucoid phenotype among the strains infecting CF...
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