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Article

Mixed Communities of Mucoid and Nonmucoid <i>Pseudomonas aeruginosa</i> Exhibit Enhanced Resistance to Host Antimicrobials

26 Mar 2018

Abstract excerpt

ABSTRACT Pseudomonas aeruginosa causes chronic pulmonary infections in patients with cystic fibrosis (CF). P. aeruginosa mucoid conversion, defined by overproduction of the exopolysaccharide alginate, correlates with accelerated decline in CF patient lung function. Recalcitrance of the mucoid phenotype to clearance by antibiotics and the immune response is well documented. However, despite advantages conferred by...

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PMID: 29588399
DOI: 10.1128/mbio.00275-18

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