Article
Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects.
Diabetes - 1 Dec 1996
Kubota A, Yamada Y, Hayami T, Yasuda K, Someya Y, Ihara Y, Kagimoto S, Watanabe R, Taminato T, Tsuda K, Seino Y
Abstract excerpt
Gastric inhibitory polypeptide (GIP) potently stimulates insulin secretion from pancreatic islets in the presence of glucose as an incretin. Because the insulinotropic effect of GIP is reduced in NIDDM, it should be clarified whether defects in the GIP receptor gene contribute to the impaired ins...
Topics
- Alleles
- Animals
- CHO Cells
- Cricetinae
- Cyclic AMP
- DNA Mutational Analysis
- DNA Primers
- Diabetes Mellitus, Type 2
- Gastric Inhibitory Polypeptide
- Humans
- Insulin
- Insulin Secretion
- Japan
- Mutation