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Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?

Human molecular genetics - 1 Sept 1995

Gough S C, Saker P J, Pritchard L E, Merriman T R, Merriman M E, Rowe B R, Kumar S, Aitman T, Barnett A H, Turner R C

Abstract excerpt

Recent evidence suggests that a mutation of the glucagon receptor (GCG-R) gene is involved in the development of type 2 diabetes in French patients. We have examined patients from three geographically distinct regions in the UK and found the GGT40 (Gly) to AGT40 (Ser) mutation to be present in 15/691 (2.2%) of patients with type 2 (non-insulin dependent) diabetes and 1/425 (0.2%) of geographically matched...

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Identifiers

PMID: 8541847
DOI: 10.1093/hmg/4.9.1609

Genes

GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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