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Article

hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing.

The EMBO journal - 15 Jul 1999

Caputi M, Mayeda A, Krainer A R, Zahler A M

Abstract excerpt

Splicing of the human immunodeficiency virus type 1 (HIV-1) pre-mRNA must be inefficient to provide a pool of unspliced messages which encode viral proteins and serve as genomes for new virions. Negative cis-regulatory elements (exonic splicing silencers or ESSs) are necessary for HIV-1 splicing inhibition. We demonstrate that heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A and B group are trans-acting...

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Source

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Identifiers

PMID: 10406810
DOI: 10.1093/emboj/18.14.4060
PMCID: PMC1171481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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