hnRNP A1 Recruited to an Exon In Vivo Can Function as an Exon Splicing Silencer

Abstract excerpt

Some exons contain exon splicing silencers. Their activity is frequently balanced by that of splicing enhancers, and this is important to ensure correct relative levels of alternatively spliced mRNAs. Using an immunoprecipitation and UV-cross-linking assay, we show that RNA molecules containing splicing silencers from the human immunodeficiency virus type 1 tat exon 2 or the human fibroblast growth factor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA and protein synthesis mechanisms
• Share to RNA Research and Splicing
• Share to Viral Infections and Immunology Research