Article
Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1999
Karperien M, Farih-Sips H, Hendriks J A, Lanske B, Papapoulos S E, Abou-Samra A B, Löwik C W, Defize L H
Abstract excerpt
We have shown previously that the PTH/PTHrP (PTH-related peptide) receptor mRNA becomes expressed very early in murine embryogenesis, i.e. during the formation of extraembryonic endoderm. Retinoic Acid (RA) is a potent inducer of extraembryonic endoderm formation and PTH/PTHrP-receptor expression in embryonal carcinoma (EC) and embryonal stem (ES) cells. Using the P19 EC cell line, we have characterized promoter...
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