Article
Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma.
Anti-cancer drug design - 1 Apr 1999
Osada M, Ishioka C, Ichinohasama R, Kadowaki I, Murakawa Y, Watanabe M, Kanamaru R, Ikawa S
Abstract excerpt
Mutations in the p53 gene were detected in 27 of the 107 (25%) cases of non-Hodgkin's lymphoma (NHL), examined by assaying the transcriptional activity of p53 in yeast. A relatively high mutation rate of p53 was observed in B-cell intermediate-grade NHL and in T-cell high-grade immunoblastic NHL, in contrast to the relatively low mutation rate observed in other pathological classifications. However, retrospective...
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