Article
Identification of two distinct subsets of long-term nonprogressors with divergent viral activity by stromal-derived factor 1 chemokine gene polymorphism analysis.
The Journal of infectious diseases - 1 Aug 1999
Balotta C, Bagnarelli P, Corvasce S, Mazzucchelli R, Colombo M C, Papagno L, Santambrogio S, Ridolfo A L, Violin M, Berlusconi A, Velleca R, Facchi G, Moroni M, Clementi M, Galli M
Abstract excerpt
Stromal-derived factor (SDF)-1, the natural ligand for CXCR4, is present in a common polymorphic variant defined by a G-->A transition in the 3' untranslated region of the gene. In persons infected with human immunodeficiency virus type 1 (HIV-1), the homozygous genotype (SDF1-3'A/3'A) has been postulated to interfere with the appearance of T-tropic syncytium-inducing strains. The polymorphism of SDF1 was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.