Article
Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progression.
The Journal of infectious diseases - 1 Nov 2005
Daar Eric S, Lynn Henry S, Donfield Sharyne M, Lail Alice, O'Brien Stephen J, Huang Wei, Winkler Cheryl A
Abstract excerpt
This study used a well characterized cohort of human immunodeficiency virus type 1 (HIV-1)-infected hemophiliacs to define the relationship between the SDF1-3'A allele, the plasma HIV-1 coreceptor tropism, and the natural history of HIV-1 disease. Subjects heterozygous or homozygous for the SDF1-3'A allele experienced higher rates of decline in CD4+ T cell counts over time than did those without the allele...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.