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Article

Identification of Pathogenic T Cells in Patients with Beryllium-Induced Lung Disease

1 Jul 1999

Abstract excerpt

Chronic beryllium disease (CBD) is caused by beryllium exposure and is characterized by granulomatous inflammation with accumulation of CD4+ T cells in the lung. We analyzed TCR beta-chain and alpha-chain genes expressed by these CD4+ T cells. In the lungs of individual patients, as well as among four of five CBD patients studied, different oligoclonal expansions within the Vbeta3 subset were found to express...

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PMID: 10395700
DOI: 10.4049/jimmunol.163.2.1019

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