Article
Transforming growth factor-beta1 and lung allograft fibrosis.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Apr 1998
El-Gamel A, Awad M, Sim E, Hasleton P, Yonan N, Egan J, Deiraniya A, Hutchinson I V
Abstract excerpt
OBJECTIVES: Transforming growth factor beta1 (TGF-beta1) is a potent immunosuppressive cytokine that promotes fibrosis by enhancing the synthesis of extracellular matrix components. The repair process following lung allograft injury is due to rejection or infection replaces lung parenchyma by fib...
Topics
- Adolescent
- Adult
- DNA Probes
- Fibrosis
- Genotype
- Graft Rejection
- Humans
- Immunohistochemistry
- Lung
- Lung Transplantation
- Middle Aged
- Transforming Growth Factor beta
- Transplantation, Homologous
