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Article

Transforming growth factor-beta1 and lung allograft fibrosis.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Apr 1998

El-Gamel A, Awad M, Sim E, Hasleton P, Yonan N, Egan J, Deiraniya A, Hutchinson I V

Abstract excerpt

OBJECTIVES: Transforming growth factor beta1 (TGF-beta1) is a potent immunosuppressive cytokine that promotes fibrosis by enhancing the synthesis of extracellular matrix components. The repair process following lung allograft injury is due to rejection or infection replaces lung parenchyma by fibrotic tissue, leading to pulmonary dysfunction. The role of TGF-beta1 in this excessive healing process and increasing...

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Identifiers

PMID: 9641342
DOI: 10.1016/s1010-7940(98)00048-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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