Article
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Molecular pharmacology - 1 Oct 1998
Harkin S T, Cohen G M, Gescher A
Abstract excerpt
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. The PKC inhibitor staurosporine induces apoptosis in many cell types. We characterized the role of PKC in the induction of apoptosis in immature rat thymocytes by investigating the effects of staur...
Topics
- Alkaloids
- Animals
- Apoptosis
- Benzimidazoles
- Cell Death
- Cell Size
- Cell Survival
- Cells, Cultured
- DNA
- Enzyme Inhibitors
- Flow Cytometry
- Male
- Nucleic Acid Conformation
- Phenotype
- Protein Kinase C
- Rats
- Rats, Inbred F344
- Staurosporine