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Article

Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.

Molecular pharmacology - 1 Oct 1998

Harkin S T, Cohen G M, Gescher A

Abstract excerpt

Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. The PKC inhibitor staurosporine induces apoptosis in many cell types. We characterized the role of PKC in the induction of apoptosis in immature rat thymocytes by investigating the effects of staurosporine with those of five analogs. Four of them, the indolocarbazoles CGP 41251 and UCN-01 and the...

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PMID: 9765509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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