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Article

Staurosporine induces astrocytic phenotypes and differential expression of specific PKC isoforms in C6 glial cells.

Journal of neurochemistry - 1 Oct 1995

Kronfeld I, Zsukerman A, Kazimirsky G, Brodie C

Abstract excerpt

In this study we examined the effects of staurosporine, a potent inhibitor of protein kinase C (PKC), on the differentiation of C6 glial cells and on the expression and cellular distribution of specific PKC isoforms. Staurosporine reduced cell proliferation and induced distinctive changes in the morphological appearance of the cells to that characteristic of cells exhibiting astrocytic phenotypes. The...

Topics

Alkaloids
Astrocytes
Cell Differentiation
Cyclic AMP
Enzyme Induction
Glial Fibrillary Acidic Protein
Glutamate-Ammonia Ligase
Isoenzymes
Neuroglia
Phenotype
Protein Kinase C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

Staurosporine

Tissue Distribution

Tumor Cells, Cultured

Source

Identifiers

PMID: 7561844
DOI: 10.1046/j.1471-4159.1995.65041505.x

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7561844-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Staurosporine induces astrocytic phenotypes and differential expression of specific PKC isoforms in C6 glial cells.PMID 7561844Read ↗

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