Article
Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B, chronic hepatitis B and hepatitis B liver cirrhosis before and after liver transplantation.
Liver - 1 Jun 1999
Rodriguez-Frias F, Buti M, Jardi R, Vargas V, Quer J, Cotrina M, Martell M, Esteban R, Guardia J
Abstract excerpt
BACKGROUND: Several studies have shown that hepatitis B immunoglobulin (HBIG) imposes a selection pressure on the hepatitis B virus (HBV) S gene, and that the emergence of mutations in this region would make reinfection after orthotopic liver transplantation (OLT) possible. AIMS: This study was undertaken to analyze the presence of HBV S-gene mutations in the different stages of HBV infection and the relationship...
Topics
- Acute Disease
- Amino Acid Substitution
- Antigenic Variation
- DNA Mutational Analysis
- Epitopes
- Gene Frequency
- Genotype
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans