Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice.

Investigative ophthalmology & visual science - 1 Jul 1999

Ikeda S, Hawes N L, Chang B, Avery C S, Smith R S, Nishina P M

Abstract excerpt

PURPOSE: To demonstrate the importance of genetic background interaction on the development of ocular phenotypes in p53-deficient mice. METHODS: Eyes of adult mice, homozygous and heterozygous for the p53 gene disruption in the 129/SvJ and C57BL/6J (B6) genetic backgrounds, and their F1 progeny were examined by indirect ophthalmoscopy and by light microscopy. RESULTS: Indirect ophthalmoscopy revealed unilateral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cataract
Share to Abnormalities, Multiple
Share to Eye Abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Diseases

Share to Mice, Inbred C3H

Share to Optic Nerve

Share to Retina

Share to Vitreous Body

Source

Identifiers

PMID: 10393064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe ocular abnormalities in C57BL/6 but not in 129/Sv p53-deficient mice.PMID 10393064Read ↗

A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.Semantic proximity Read ↗

Differential manifestation of ocular phenotypes in TALEN-mediated p19arf knockout FVB/N and C57BL/6J mouse lines.Semantic proximity Read ↗

Effects of elevated Pax6 expression and genetic background on mouse eye development.Semantic proximity Read ↗

Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice.Semantic proximity Read ↗

Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice.Semantic proximity Read ↗

Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.Semantic proximity Read ↗

A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).Semantic proximity Read ↗

The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent.Semantic proximity Read ↗

A note on the genetics of a unilateral senile cataract in mice.Semantic proximity Read ↗

Lens aplasia: a new mutation producing lens abnormality in the mouse.Semantic proximity Read ↗

The influence of genetic background on conventional outflow facility in mice.Semantic proximity Read ↗

Dense cataract and microphthalmia--new spontaneous mutation in BALB/c mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.