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Article

A mouse model for Stickler's syndrome: ocular phenotype of mice carrying a targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1).

Experimental eye research - 1 Aug 2006

Kaarniranta Kai, Ihanamäki Tapio, Sahlman Janne, Pulkkinen Hertta, Uusitalo Hannu, Arita Machiko, Tammi Raija, Lammi Mikko J, Helminen Heikki J

Abstract excerpt

The influences of targeted heterozygous inactivation of type II (pro)collagen gene (Col2a1) on eye structures in the 15-month-old C57BL/6JOlaHsd mouse was studied. The eyes were collected from C57BL mice heterozygous for a targeted inactivation of one allele of the Col2a1 gene (Col2a1(+/-) mice). The eyes of C57BL mice with normal gene alleles were used as controls (Col2a1(+/+) mice). Ocular histology was...

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Identifiers

PMID: 16546167
DOI: 10.1016/j.exer.2005.11.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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