Article
Prevalence of tumor necrosis factor-alpha and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma.
American journal of respiratory and critical care medicine - 1 Jul 1999
Chagani T, Paré P D, Zhu S, Weir T D, Bai T R, Behbehani N A, Fitzgerald J M, Sandford A J
Abstract excerpt
Allele 2 of the polymorphism at position -308 in the promoter of the tumor necrosis factor alpha (TNF-alpha) gene, and the D allele of the angiotensin converting enzyme (ACE) gene, have been associated with asthma. We hypothesized that genotypes containing these alleles would show an increased prevalence in asthmatic as compared with nonasthmatic individuals, and would be associated with asthma severity....
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